/ 0

Store

Craniomandibular Osteopathy (Terrier Type)

$50

(ONLINE PRICE)

ADD TO CART

Test Overview:

Sometimes called “Westie jaw” or “Scottie jaw” by breeders, this is a disease most commonly seen in young West Highland white terriers, Scottish terriers and Cairn terriers that is thought to be inherited as an autosomal dominant trait with incomplete penetrance. The disease causes proliferation of the lower jaw bone, as well as the tympanic bullae (part of the inner ear bones), and can sometimes affect other bones of the head. This causes abnormal enlargement of the bones when the bones are growing (i.e. when the dog is young), and can lead to some problems with chewing and swallowing, and difficulty opening the mouth. Some affected puppies will have pain when opening their mouth. This is usually a self-limiting disease, seen in dogs around four to eight months of age with signs of discomfort when eating or chewing. Excessive bone growth slows and then stops at around a year of age, and in some cases may even recede somewhat. Often treatment is symptomatic only, with soft foods and anti-inflammatories/pain relief.

Category:

Musculoskeletal - Associated with muscles, bones and associated structures

Gene:

SLC37A2

Variant Detected:

chr5:9387327 (canFam3): C>T

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Dominant with Incomplete Penetrance

Research Citation(s):

Hytonen MK, Arumilli M, Lappalainen AK, Owczarek-Lipska, Jagannathan V, Hundi S, Salmela E, Venta P, Sarkiala E, Jokinen T, Gorgas D, Kere J, Nieminen P, Drogemuller C, Lohi H. Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes. PLoS Genet. 2016 May 17;12(5):e1006037. doi: 10.1371/journal.pgen.1006037. [PubMed: 27187611] Padgett GA, Mostosky UV. The mode of inheritance of craniomandibular osteopathy in West Highland White terrier dogs. Am J Med Genet. 1986 Sep;25(1):9-13. [PubMed: 3799725] Shorenstein B, Schwartz P, Kross PH. What is your diagnosis? Craniomandibular osteopathy. J Am Vet Med Assoc. 2014 Sep 1;245(5):491-2. doi: 10.2460/javma.245.5.491. [PubMed: 25148087]

Associated Breed(s):

Australian Shepherd, Cairn Terrier, Mixed Breed, Scottish Terrier , West Highland White Terrier ,

##parent-placeholder-19bd1503d9bad449304cc6b4e977b74bac6cc771##