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K Locus (Dominant Black)

K Locus (Dominant Black)

$50

(ONLINE PRICE)

Test Overview:

The KB variant of the CBD103 gene promotes eumelanin (black pigment) synthesis by blocking the agouti gene expression at the A Locus (which would otherwise inhibit MC1R production of eumelanin). The alternate ky variant of the CBD103 gene disrupts the normal function of the CBD103 gene allowing for agouti (A locus) gene expression and the inhibition of black pigment synthesis. Therefore, because KB is dominant, only one copy of KB is required to inhibit agouti gene expression.

Category:

Trait (Associated with Phenotype)

Gene:

CBD103

Variant Detected:

chr16:58965448-58965450 (canFam3): 3 bp deletion (del GGA)

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Dominant

Recommended Screening:

Genetic testing of the CBD103 gene for the KB variant will determine if a dog is a genetic carrier of agouti gene expression. The K locus is important to understanding whether or not a dog will express agouti traits in its coat colour or if it can pass on agouti expression to its offspring.

Research Citation(s):


"Conditions Associated with Coat Color in Dogs." University of Saskatchewan. University of Saskatchewan, 02 June 2011. Web. 03 Apr. 2014. .
Dog Coat Colour Genetics http://doggenetics.co.uk/
Everts RE, Rothuizen J, van Oost BA. Identification of a premature stop codon in the melanocyte-stimulating hormone receptor gene (MC1R) in Labrador and Golden retrievers with yellow coat color. Animal Genetics. 2000 Jun; 31(3):194-99. [PubMed: 10895310]

Associated Breed(s):

Affenpinscher, Afghan Hound, Airedale Terrier, Akita , Alaskan Husky, Alaskan Klee Kai, Alaskan Malamute, American Bulldog , American Bully (Micro/Pocket/Classic/XL), American Cocker Spaniel, American Eskimo Dog, American Foxhound, American Pit Bull Terrier, American Staffordshire Terrier, Anatolian Shepherd, Asian Shepherd, Australian Bulldog, Australian Cattle Dog, Australian Cobberdog, Australian Kelpie, Australian Labradoodle , Australian Shepherd, Australian Silky Terrier, Australian Stumpy Tail Cattle Dog, Australian Terrier, Azawakh, Barbet, Basenji, Basset Fauve De Bretagne , Basset Hound, Beagle, Bearded Collie , Beauceron, Bedlington Terrier, Belgian Groenendael Shepherd, Belgian Lakenois Shepherd, Belgian Malinois Shepherd, Belgian Tervueren Shepherd , Bergamasco Shepherd, Bernedoodle, Bernese Mountain Dog, Bichon Frise, Biewer Terrier, Black Russian Terrier , Bloodhound, Boerboel, Border Collie, Border Terrier, Borzoi, Boston Bulldog, Boston Terrier, Bouvier Des Flandres, Boxer , Boykin Spaniel, Brazilian Terrier, Briard, British Bulldog, Brittany Spaniel , Bull Arab, Bull Terrier, Bulldog, Bullmastiff, Cairn Terrier, Canaan Dog, Cane Corso, Cardigan Welsh Corgi, Catahoula, Catahoula Leopard Dog, Caucasian Shepherd Dog, Cavador, Cavalier King Charles Spaniel, Cavoodle, Central Asian Shepherd Dog, Chesapeake Bay Retriever , Chihuahua, Chinese Crested, Chinese Shar-Pei, Chinook, Chow Chow, Clumber Spaniel , Cockapoo, Cocker Spaniel, Collie Rough, Collie Smooth, Colonial Cocker Spaniel, Coonhound, Coton De Tulear, Czechoslovakian Vlack, Czechoslovakian Wolfdog, Dachshund , Dachshund Short Hair, Dachshund Standard Long Hair, Dachshund Standard Smooth Hair, Dachshund Standard Wire Hair, Dachshund Wire Hair, Dalmatian, Dandie Dinmont Terrier, Dingo, Dobermann, Dogue de Bordeaux, Double Doodle, Drentsche Patrijshond, Drever, Dutch Shepherd, Dwarf Poodle, English Cocker Spaniel, English Pointer, English Setter , English Shepherd, English Springer Spaniel, English Toy Spaniel , English Toy Terrier, Estrela Mountain Dog, Eurasier, Field Spaniel, Finnish Hound, Finnish Lapphund, Flat Coated Retriever, Foxhound , French Bulldog, German Pinscher, German Shepherd Dog, German Shorthaired Pointer, German Spaniel, German Spitz , Giant Schnauzer, Golden Retriever, Goldendoodle, Gordon Setter , Great Dane, Great Pyrenees, Greyhound , Griffon Bruxellois - Standard, Groodle, Hamiltonstövare, Hangin' Tree Cowdog, Harlequin Pinscher, Havanese, Havanese Terrier Toy, Hungarian Kuvasz, Hungarian Vizsla, Huntaway, Ibizan Hound, Icelandic Sheepdog, Irish Setter, Irish Terrier, Irish Wolfhound, Italian Greyhound, Italian Spinone, Jack Russell Terrier, Jagd Terrier, Japanese Akita Inu, Japanese Chin, Japanese Shiba Inu, Japanese Spitz, Kangal Shepherd Dog, Karelian Bear Dog, Keeshond, Kerry Blue Terrier, King Charles Spaniel, Komondor, Kooikerhondje, Koolie , Kromfohrländer, Kuvasz, Labradoodle , Labradoodle Retrodoodle , Labrador Retriever, Lagotto Romagnolo, Lakeland Terrier , Lancashire Heeler, Landseer ECT, Lapponian Herder, Large Munsterlander, Leonberger, Lhasa Apso, Lowchen, Maltese, Manchester Terrier , Maremma Sheepdog, Mastiff , Miki, Miniature American Shepherd, Miniature Australian Bulldog, Miniature Australian Shepherd, Miniature Bull Terrier, Miniature Dachshund, Miniature Dachshund Long Hair, Miniature Dachshund Short Hair, Miniature Dachshund Smooth Hair, Miniature Dachshund Wire Hair, Miniature Fox Terrier, Miniature Pinscher , Miniature Poodle, Miniature Schnauzer, Miniature Yorkshire Terrier, Moodle, Mountain Curr, Mountain Dog , Moyen Poodle, Mudi, Munsterlander, Murray River Retriever, Neapolitan Mastiff, Newfoundland, Norfolk Terrier , Norwegian Elkhound, Norwich Terrier, Nova Scotia Duck Tolling Retriever , Old English Mastiff , Old English Sheepdog , Otterhound, Papillon, Parson Russell Terrier, Patterdale Terrier, Pekingese, Pembroke Welsh Corgi, Peruvian Hairless Dog, Phalene, Plott Hound, Pointer, Polish Lowland Sheepdog, Pomeranian, Portuguese Podengo, Portuguese Water Dog, Prague Ratter, Presa de Canario, Pug, Puli, Pumi, Pyrenean Sheepdog, Rat Terrier, Rhodesian Ridgeback , Rottweiler , Russian Toy, Saint Bernard , Saluki, Samoyed, Sarplaninac, Schapendoes, Schipperke, Schnoodle, Scotch Collie, Scottish Deerhound, Scottish Terrier , Sealydale Terrier, Sealyham Terrier , Shar Pei, Shetland Sheepdog, Shiba Inu, Shih tzu, Shikoku, Short Bully, Shortybull, Siberian Husky, Silky Terrier , Skye Terrier, Sloughi, Smithfield, Smooth Fox Terrier, Soft Coated Wheaten Terrier, Spanatriever, Spanish Greyhound, Spanish Water Dog, Spoodle, Staffordshire Bull Terrier , Standard Poodle, Standard Schnauzer, Sussex Spaniel, Swedish Lapphund, Swedish Vallhund, Tenterfield Terrier , Thai Ridgeback, Theodore, Tibetan Mastiff, Tibetan Spaniel, Tibetan Terrier , Toy Fox Terrier, Toy Poodle, Treeing Walker Coonhound, Unknown, Volpino Italiano, Water Spaniel , Weimaraner, Welsh Springer Spaniel, Welsh Terrier , West Highland White Terrier , Whippet , White Swiss Shepherd, Wire Fox Terrier, Xoloitzcuintle (Mexican Hairless), Yakutian Laika, Yorkshire Terrier,
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