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Adult Onset Deafness Border Collie (Linkage Association Test)

$50

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Test Overview:

Use linkage association genetic tests to identify carriers or at-risk dogs. Avoid breeding dogs that test positive for high-risk SNP markers associated with adult onset deafness. Prefer breeding dogs confirmed as clear to reduce disease incidence. Due to the dominant inheritance and variable expression, breeding decisions require careful assessment of pedigree, clinical hearing status, and genetic test results. Breed clubs and genetic testing providers can supply guidelines specific to Border Collies.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

USP31

Variant Detected:

c.846+5 T>G

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Complex - Mode Unknown

Research Citation(s):

Yokoyama, 2019, PLoS Genet 8(9): e1002898
2014 Schmutz, S.M. : An analysis of the inheritance pattern of an adult-onset hearing loss in Border Collie dogs. Canine Genet Epidemiol 1:6, 2014. Pubmed reference: 26401323. DOI: 10.1186/2052-6687-1-6.
2012 Yokoyama, J.S., Lam, E.T., Ruhe, A.L., Erdman, C.A., Robertson, K.R., Webb, A.A., Williams, D.C., Chang, M.L., Hytönen, M.K., Lohi, H., Hamilton, S.P., Neff, M.W. : Variation in genes related to cochlear biology is strongly associated with adult-onset deafness in border collies. PLoS Genet 8:e1002898, 2012. Pubmed reference: 23028339. DOI: 10.1371/journal.pgen.1002898.

Associated Breed(s):

Australian Shepherd, Border Collie, Bordoodle, Collie Rough, Collie Smooth,

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