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Multiple Drug Resistance (Feline)

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Test Overview:

Genetic testing for the MDR1 (ABCB1) mutation in breeding cats is strongly recommended. Cats with two copies of the mutation (affected) should not be bred, as they can produce affected offspring sensitive to common drugs. Cats with one copy (carriers) should only be bred to cats clear of the mutation. Avoid breeding two carriers together as this risks producing affected kittens with two copies of the mutation. If a carrier is bred with a clear cat, about 50% of kittens will be carriers but healthy. Knowledge of a cat’s MDR1 status is important for safe veterinary care, especially when using drugs known to cause adverse reactions in affected cats. Breeders and owners should share test results openly for responsible breeding and medical management.

Category:

Trait (Associated with Phenotype)

Gene:

ABCB1

Variant Detected:

c.1930_1931del

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing can determine if a cat is a carrier for Multiple Drug Resistance.

Research Citation(s):

Mealey, K.L., Burke, N.S. : Identification of a nonsense mutation in feline ABCB1. J Vet Pharmacol Ther 38:429-33, 2015. Pubmed reference: 25660379.

Associated Breed(s):

Abyssinian, African Short Hair, American Bobtail , American Curl, American Domestic Cat, American Ringtail, American Shorthair, Angora, Asian, Australian Mist , Balinese, Bambino, Bengal, Birman, Bombay, British Black Tipped, British Domestic Cat, British Longhair, British Red Spot, British Shorthair, British Shorthair/Longhair, Burmese, Burmilla, Calico, California Spangled, Caracat, Chantilly, Chartreux, Chausie, Cheetoh, Chinchilla, Colourpoint Shorthair, Colourpoint Siberian Forest Cat, Cornish Rex, Devon Rex, Domestic Leopard Cat, Domestic Medium / Long Hair, Domestic Short Hair, Don Hairless, Don Sphynx, Donskoy, Egyptian Black, Egyptian Mau, Egyptian Street Cat, Elf Cat, European, European Domestic Cat, Exotic , Exotic Longhair, Exotic Shorthair, Foreign White, German Rex, Havana Brown, Highland Fold, Highlander, Himalayan, Indian Street Cat, Iranian Street Cat, Irish Domestic Cat, Japanese Bobtail, Javanese, Kenyan Street Cat, Khao Manee, Korat, Korean Street Cat, Kurilian Bobtail Short Haired, LaPerm , Lebanese Street Cat, Lykoi, Maine Coon, Mandalay, Manx , Minuet, Mixed Breed / Unknown Breed (Feline), Munchkin Short/Long Haired, Nebelung, Neva Masquerade, Norwegian Forest Cat, Ocicat, Ojos Azules, Omani Street Cat, Oriental , Oriental Long Hair, Oriental Short Hair, Persian , Persian Blue, Persian Colourpoint, Persian Smoke, Persian Tabby, Peterbald, PixieBob, Ragamuffin, Ragdoll, Rex , Russian Black, Russian Blue, Russian White, Savannah, Scottish Fold, Scottish Fold Long Haired, Scottish Fold Short Haired, Scottish Short Hair, Scottish Straight, Scottish Wildcat, Selkirk Rex, Serengeti, Seychellois Short/Long Hair, Siamese, Siberian, Siberian Forest Cat, Singapura, Snowshoe, Sokoke, Somali , Somali Long Hair, Somali Short Hair, Sphynx, Tennessee Rex, Thai Street Cat, Tiffany, Tonkinese, Toybob, Toyger, Turkish Angora, Turkish Van, York Chocolate,
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