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Multiple Drug Resistance (Feline)

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Test Overview:

Multiple Drug Resistance results in increased risk of adverse reactions with the P-glycoprotein substrates (such as ivermectin and macrocyclic lactones). These are commonly found in tick and flea preventative products for cats (and dogs). Characteristics are neurological and can include ataxia, central nervous system depression, vomiting, salivation, tremors, respiratory disturbances, mydriasis, and in some severe cases, coma or death.

Category:

Haemolymphatic - Associated with the blood and lymph

Gene:

ABCB1

Variant Detected:

c.1930_1931del

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Dominant with Variable Expressivity

Recommended Screening:

Genetic testing can determine if a cat is a carrier for Multiple Drug Resistance.

Research Citation(s):

Mealey, K.L., Burke, N.S. : Identification of a nonsense mutation in feline ABCB1. J Vet Pharmacol Ther 38:429-33, 2015. Pubmed reference: 25660379.

Associated Breed(s):

Mixed Breed / Unknown Breed (Feline),
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