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Brown TYRP1 [Lancashire Heeler Type] = Bl

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Test Overview:

Avoid breeding two carriers of Bl alleles if brown coat color is not desired, since there is a 25% chance of producing brown puppies per litter. Breed carriers (heterozygous for Bl) only to clear (non-carrier) dogs to prevent brown puppies but retain genetic diversity. If brown coat color is desirable, breeders can select for homozygous Bl dogs responsibly. Routine genetic testing for the TYRP1 gene variants, including Bl, is recommended for Lancashire Heelers to guide breeding decisions.

Category:

Trait (Associated with Phenotype)

Gene:

TYRP1

Variant Detected:

T>G, Chr11:33326719

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Wright HE, Schofield E, Mellersh CS, Burmeister LM. A novel TYRP1 variant is associated with liver and tan coat colour in Lancashire Heelers. Anim Genet. 2019 Dec;50(6):783. doi: 10.1111/age.12839. Epub 2019 Aug 29. [PubMed: 31468558]

Associated Breed(s):

Lancashire Heeler, Unknown,
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