B Locus - Bd, Bs, Bc [Various Breeds]

Category:

Trait (Associated with Phenotype)

Gene:

TYRP1

Variant Detected:

bc = T>A, Chr11:33317810; bd = 3 bp deletion (del CCT) Chr11:33326727-33326729; bs = C>T, Chr11:33326685

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the TYRP1 gene will reliably determine if a dog is a carrier for B Locus - Bd, Bs, Bc.

Research Citation(s):

Hrckova Turnova E, Majchrakova Z, Bielikova M, Soltys K, Turna J, Dudas A. A novel mutation in the TYRP1 gene associated with brown coat color in the Australian Shepherd Dog Breed. Anim Genet. 2017 Oct; 48(5):626. [PubMed: 28497851] Schmutz SM, Berryere TG, Goldfinch AD. TYRP1 and MC1R genotypes and their effects on coat color in dogs. Mamm Genome. 2002 Jul; 13(7):380-7. [PubMed: 12140685] Van Buren SL, Mickelson JR, Minor KM. A novel TYRP1 mutation associated with brown coat color in Siberian huskies. Anim Genet. 2021 Apr;52(2):245-246. doi: 10.1111/age.13037. Epub 2021 Jan 9. [PubMed: 33421162] Wright HE, Schofield E, Mellersh CS, Burmeister LM. A novel TYRP1 variant is associated with liver and tan coat colour in Lancashire Heelers. Anim Genet. 2019 Dec;50(6):783. doi: 10.1111/age.12839. Epub 2019 Aug 29. [PubMed: 31468558]

Associated Breed(s):

Affenpinscher, Afghan Hound, Airedale Terrier, Akita , Alaskan Husky, Alaskan Klee Kai, Alaskan Malamute, American Bulldog , American Bully (Micro/Pocket/Classic/XL), American Cocker Spaniel, American Eskimo Dog, American Foxhound, American Hairless (Rat) Terrier, American Pit Bull Terrier, American Staffordshire Terrier, Anatolian Shepherd, Asian Shepherd, Aussiedoodle, Australasian Bosdog, Australian Bulldog, Australian Cattle Dog, Australian Cobberdog, Australian Kelpie, Australian Labradoodle , Australian Shepherd, Australian Silky Terrier, Australian Stumpy Tail Cattle Dog, Australian Terrier, Basenji, Basset Fauve De Bretagne , Basset Hound, Beagle, Bearded Collie , Bedlington Terrier, Belgian Groenendael Shepherd, Belgian Lakenois Shepherd, Belgian Malinois Shepherd, Belgian Tervueren Shepherd , Bernardoodle, Bernedoodle, Bernese Mountain Dog, Bichon Frise, Black Russian Terrier , Bloodhound, Boerboel, Border Collie, Border Terrier, Bordoodle, Borzoi, Boston Terrier, Bouvier Des Flandres, Boxer , Boykin Spaniel, Bracco Italiano, Brazilian Terrier, Briard, British Bulldog, Brittany Spaniel , Bull Arab, Bull Terrier, Bullmastiff, Cairn Terrier, Canaan Dog, Cane Corso, Cardigan Welsh Corgi, Catahoula, Catahoula Leopard Dog, Cavador, Cavalier King Charles Spaniel, Cavoodle, Central Asian Shepherd Dog, Chesapeake Bay Retriever , Chihuahua, Chinese Crested, Chow Chow, Clumber Spaniel , Cockapoo, Cocker Spaniel, Collie Rough, Collie Smooth, Coonhound, Coton De Tulear, Curly Coated Retriever, Czechoslovakian Vlack, Dachshund , Dachshund Short Hair, Dachshund Standard Long Hair, Dachshund Standard Smooth Hair, Dachshund Standard Wire Hair, Dachshund Wire Hair, Dalmatian, Dandie Dinmont Terrier, Dingo, Dobermann, Dogo Argentino, Dogue de Bordeaux, Drentsche Patrijshond, Drever, Dutch Shepherd, Dwarf Poodle, English Cocker Spaniel, English Pointer, English Setter , English Shepherd, English Springer Spaniel, English Toy Spaniel , English Toy Terrier, Entlebucher Mountain Dog, Estrela Mountain Dog, Eurasier, Field Spaniel, Finnish Hound, Finnish Lapphund, Finnish Spitz, Flat Coated Retriever, Foxhound , French Bulldog, German Pinscher, German Shepherd Dog, German Shorthaired Pointer, German Spitz , German Wirehaired Pointer, Giant Schnauzer, Glen of Imaal Terrier, Golden Retriever, Goldendoodle, Gordon Setter , Grand Basset Griffon Vendeen, Great Dane, Great Pyrenees, Greater Swiss Mountain Dog, Greyhound , Griffon Bruxellois - Standard, Groodle, Harlequin Pinscher, Havanese, Havanese Terrier Toy, Hungarian Kuvasz, Hungarian Vizsla, Hungarian Wirehaired Vizsla, Huntaway, Ibizan Hound, Irish Setter, Irish Terrier, Irish Water Spaniel, Irish Wolfhound, Italian Greyhound, Italian Spinone, Jack Russell Terrier, Jagd Terrier, Japanese Akita Inu, Japanese Chin, Japanese Shiba Inu, Japanese Spitz, Kangal Shepherd Dog, Kaninchen Dachshund, Karelian Bear Dog, Keeshond, Kerry Blue Terrier, Komondor, Kooikerhondje, Koolie , Kromfohrländer, Kuvasz, Labradoodle , Labradoodle Retrodoodle , Labrador Retriever, Lagotto Romagnolo, Lakeland Terrier , Lancashire Heeler, Landseer ECT, Lapponian Herder, Large Munsterlander, Leonberger, Lhasa Apso, Lowchen, Maltese, Manchester Terrier , Maremma Sheepdog, Mastiff , Miki, Miniature American Shepherd, Miniature Australian Bulldog, Miniature Australian Shepherd, Miniature Bull Terrier, Miniature Dachshund, Miniature Dachshund Long Hair, Miniature Dachshund Short Hair, Miniature Dachshund Smooth Hair, Miniature Dachshund Wire Hair, Miniature Fox Terrier, Miniature Pinscher , Miniature Poodle, Miniature Schnauzer, Miniature Yorkshire Terrier, Moodle, Mountain Dog , Moyen Poodle, Munsterlander, Murray River Retriever, Native American Indian Dog, Neapolitan Mastiff, New Zealand Heading Dog, Newfoundland, Norfolk Terrier , Norwegian Elkhound, Norwich Terrier, Nova Scotia Duck Tolling Retriever , Old Danish Pointing Dog, Old English Mastiff , Old English Sheepdog , Otterhound, Papillon, Parson Russell Terrier, Pekingese, Pembroke Welsh Corgi, Peruvian Hairless Dog, Petit Basset Griffon Vendeen, Phalene, Pharaoh Hound, Plott Hound, Pointer, Polish Lowland Sheepdog, Pomeranian, Portuguese Podengo, Portuguese Water Dog, Prague Ratter, Presa de Canario, Pug, Puli, Pumi, Pyrenean Mastiff, Rat Terrier, Red and White Setter, Rhodesian Ridgeback , Rottweiler , Russian Toy, Saint Bernard , Saluki, Samoyed, Sarplaninac, Schapendoes, Schipperke, Schnoodle, Scottish Deerhound, Scottish Terrier , Sealydale Terrier, Sealyham Terrier , Shar Pei, Shetland Sheepdog, Shiba Inu, Shih tzu, Short Bully, Shortybull, Siberian Husky, Silky Terrier , Skye Terrier, Sloughi, Smithfield, Smooth Fox Terrier, Soft Coated Wheaten Terrier, Spanish Water Dog, Spoodle, Staffordshire Bull Terrier , Standard Poodle, Standard Schnauzer, Sussex Spaniel, Swedish Lapphund, Swedish Vallhund, Tenterfield Terrier , Thai Ridgeback, Tibetan Mastiff, Tibetan Spaniel, Tibetan Terrier , Toy Australian Shepherd, Toy Fox Terrier, Toy Poodle, Treeing Walker Coonhound, Unknown, Volpino Italiano, Water Spaniel , Weimaraner, Weimaraner Long Hair , Welsh Springer Spaniel, Welsh Terrier , West Highland White Terrier , Whippet , White Swiss Shepherd, Wire Fox Terrier, Wirehaired Vizsla, Wolf, Xoloitzcuintle (Mexican Hairless), Yorkshire Terrier,