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A Locus (Agouti)

A Locus (Agouti)

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Test Overview:

the agouti-signalling peptide (ASIP) gene have identified four different alleles that affect the pigmentation of coat colour in dogs. In dogs that do not carry the dominant black gene (ky/ky at the K Locus) and are not "e/e" for the E Locus, the agouti gene is allowed to express and determines the colour of the dog's coat. The four alleles work as a hierarchy, with the most dominant allele that the dog has always being expressed (assuming n/n for the K Locus). The most dominant allele is "ay", followed by "aw", then "at", then "a." The Ay variant of ASIP inhibits the MC1R gene (E locus) causing a switch from eumelanin to phaeomelanin production resulting in a sable/fawn coat color. The aw variant of ASIP produces a "wolf" sable/gray coat color. Other variations of ASIP, such as the at and a gene variants, impact canine coat color by producing tricolor/black and tan or bicolor/solid black coat colors, respectively. The variants of the ASIP gene are expressed in a hierarchical manner with Ay being dominant to and expressed over aw, aw being dominant to and expressed over at, and at being dominant to and expressed over a. However, the dog's coat color is also dependent on the dog's genotypes at the E, K, and B genes among others.

Category:

Trait (Associated with Phenotype)

Gene:

ASIP

Variant Detected:

Ay = A>G, Chr24:23393514, T>G, Chr24:23393510; aw/at = 239 bp insertion, Chr24:23365283-23365284; a = C>T, Chr24:23393552

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Dreger DL, Parker HG, Ostrander EA, Schmutz SM. Identification of a mutation that is associated with the saddle tan and black-and-tan phenotypes in Basset Hounds and Pembroke Welsh Corgis. J Hered. 2013 May-Jun; 104(3):399-406. [PubMed: 23519866] Dreger DL, Schmutz SM. A SINE insertion causes the black-and-tan and saddle tan phenotypes in domestic dogs. J Hered. 2011 Sep-Oct; 102 Suppl 1:S11-8. [PubMed: 21846741] Kerns JA, Newton J, Berryere TG, Rubin EM, Cheng JF, Schmutz SM, Barsh GS. Characterization of the dog Agouti gene and a nonagouti mutation in German Shepherd Dogs. Mamm Genome. 2004 Oct; 15(10):798-808. [PubMed: 15520882]

Associated Breed(s):

Affenpinscher, Afghan Hound, Airedale Terrier, Akita , Alaskan Malamute, American Bulldog , American Cocker Spaniel, American Eskimo Dog, American Foxhound, American Pit Bull Terrier, American Staffordshire Terrier, Anatolian Shepherd, Australian Bulldog, Australian Cattle Dog, Australian Cobberdog, Australian Kelpie, Australian Labradoodle , Australian Shepherd, Australian Silky Terrier, Australian Stumpy Tail Cattle Dog, Australian Terrier, Basenji, Basset Hound, Beagle, Bearded Collie , Bedlington Terrier, Belgian Groenendael Shepherd, Belgian Lakenois Shepherd, Belgian Malinois Shepherd, Belgian Tervueren Shepherd , Bernese Mountain Dog, Bichon Frise, Black Russian Terrier , Bloodhound, Boerboel, Border Collie, Border Terrier, Borzoi, Boston Bulldog, Boston Terrier, Bouvier Des Flandres, Boxer , Boykin Spaniel, Briard, British Bulldog, Brittany Spaniel , Bull Arab, Bull Terrier, Bullmastiff, Cairn Terrier, Canaan Dog, Cane Corso Italiano, Catahoula, Catahoula Leopard Dog, Cavalier King Charles Spaniel, Cavoodle, Chesapeake Bay Retriever , Chihuahua, Chinese Crested, Chow Chow, Clumber Spaniel , Cockapoo, Cocker Spaniel, Collie Rough, Collie Smooth, Coonhound, Coton De Tulear, Curly Coated Retriever, Dachshund , Dachshund Standard Long Hair, Dachshund Standard Smooth Hair, Dachshund Standard Wire Hair, Dalmatian, Dandie Dinmont Terrier, Dingo, Dobermann, Dogue de Bordeaux, English Setter , English Springer Spaniel, English Toy Spaniel , English Toy Terrier, Field Spaniel, Finnish Lapphund, Flat Coated Retriever, Fox Terrier (Toy), Foxhound , French Bulldog, German Shepherd Dog, German Shorthaired Pointer, German Spitz , Giant Schnauzer, Golden Retriever, Goldendoodle, Gordon Setter , Great Dane, Great Pyrenees, Greyhound , Griffon Bruxellois - Standard, Groodle, Harlequin Pinscher, Havanese, Havanese Terrier Toy, Hungarian Kuvasz, Hungarian Vizsla, Ibizan Hound, Irish Setter, Irish Terrier, Irish Wolfhound, Italian Greyhound, Italian Spinone, Jack Russell Terrier, Jagd Terrier, Japanese Chin, Japanese Shiba Inu, Japanese Spitz, Kaninchen Dachshund, Keeshond, Kerry Blue Terrier, Komondor, Koolie , Labradoodle , Labrador Retriever, Lagotto Romagnolo, Lakeland Terrier , Lancashire Heeler, Landseer ECT, Lapponian Herder, Leonberger, Lhasa Apso, Lowchen, Maltese, Manchester Terrier , Maremma Sheepdog, Mastiff , Miki, Miniature American Shepherd, Miniature Bull Terrier, Miniature Dachshund Long Hair, Miniature Dachshund Smooth Hair, Miniature Dachshund Wire Hair, Miniature Fox Terrier, Miniature Pinscher , Miniature Poodle, Miniature Schnauzer, Miniature Yorkshire Terrier, Mixed Breed, Mountain Dog , Munsterlander, Murray River Retriever, Neapolitan Mastiff, Newfoundland, Norfolk Terrier , Norwegian Elkhound, Norwich Terrier, Nova Scotia Duck Tolling Retriever , Old English Mastiff , Old English Sheepdog , Papillon, Parson Russell Terrier, Pekingese, Pembroke Welsh Corgi, Peruvian Hairless Dog, Plott Hound, Pomeranian, Portuguese Water Dog, Pug, Puli, Rat Terrier, Rhodesian Ridgeback , Rottweiler , Saint Bernard , Saluki, Samoyed, Schipperke, Schnoodle, Scottish Deerhound, Scottish Terrier , Sealydale Terrier, Sealyham Terrier , Shar Pei, Sheepadoodle, Shetland Sheepdog, Shiba Inu, Shih tzu, Shmoodle, Shoodle, Short Bully, Shortybull, Siberian Husky, Silky Terrier , Skye Terrier, Sloughi, Smithfield, Smooth Fox Terrier, Soft Coated Wheaten Terrier, Spoodle, Staffordshire Bull Terrier , Standard Poodle, Standard Schnauzer, Sussex Spaniel, Swedish Lapphund, Tenterfield Terrier , Tibetan Mastiff, Tibetan Spaniel, Tibetan Terrier , Toy Poodle, Volpino Italiano, Water Spaniel , Weimaraner, Welsh Springer Spaniel, West Highland White Terrier , Whippet , White Swiss Shepherd, Wire Fox Terrier, Xoloitzcuintle (Mexican Hairless), Yorkshire Terrier,
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