Exercise Induced Collapse (Retriever Type)

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

DNM1

Variant Detected:

Base Substitution c.767 G>T

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive with Incomplete Penetrance

Recommended Screening:

DNA test available for dynamin-1 mutation, recommend screen all breeding animals by 1 year of age.

Research Citation(s):

Furrow E, Minor KM, Taylor SM, Mickelson JR, Patterson EE. Relationship between dynamin 1 mutation status and characteristics of recurrent episodes of exercise-induced collapse in Labrador Retrievers. J Am Vet Med Assoc. 2013 Mar 15;242(6):786-91. [PubMed: 23445289] Minor KM, Patterson EE, Keating MK, Gross SD, Ekenstedt KJ, Taylor SM, Mickelson JR. Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds. Vet J. 2011 Aug; 189(2):214-9. [PubMed: 21782486] Patterson EE, Minor KM, Tchernatynskaia AV, Taylor SM, Shelton GD, Ekenstedt KJ, Mickelson JR. A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse. Nat Genet. 2008 Oct; 40(10):1235-9. [PubMed: 18806795] Taylor SM, Shmon CL, Adams VJ, Mickelson JR, Patterson EN, Shelton GD. Evaluations of labrador retrievers with exercise-induced collapse, including response to a standardized strenuous exercise protocol. J Am Anim Hosp Assoc. 2009 Jan-Feb; 45(1):3-13. [PubMed: 19122058] Taylor SM, Shmon CL, Shelton GD, Patterson EN, Minor K, Mickelson JR. Exercise-induced collapse of Labrador retrievers: survey results and preliminary investigation of heritability. J Am Anim Hosp Assoc. 2008 Nov-Dec; 44(6):295-301. [PubMed: 18981194]

Associated Breed(s):

American Cocker Spaniel, Australian Cobberdog, Australian Labradoodle , Australian Shepherd, Bernardoodle, Bouvier Des Flandres, Boykin Spaniel, Cardigan Welsh Corgi, Catahoula, Catahoula Leopard Dog, Cavador, Chesapeake Bay Retriever , Clumber Spaniel , Cocker Spaniel, Curly Coated Retriever, German Wirehaired Pointer, Golden Retriever, Goldendoodle, Hungarian Vizsla, Labradoodle , Labradoodle Retrodoodle , Labrador Retriever, Miniature Australian Shepherd, Mixed Breed, Old English Sheepdog , Pembroke Welsh Corgi, Toy Australian Shepherd,