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Factor VII Deficiency

Factor VII Deficiency

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Test Overview:

Test breeding dogs in predisposed breeds (e.g., Beagles, Airedale Terriers, Dachshunds, German Wirehaired Pointers, Schnauzers). Avoid breeding two carriers to prevent affected offspring. Breed carriers only to genetically clear dogs, testing offspring accordingly. Promote genetic diversity while reducing disease incidence.

Category:

Haemolymphatic - Associated with the blood and lymph

Gene:

Coagulation factor VII (F7) Chromosome 22

Variant Detected:

Base Substitution c.407G>A p.Gly136Glu

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the F7 gene in dogs will reliably determine if a dog is a genetic carrier of coagulation factor VII deficiency.

Research Citation(s):

Callan MB, et al. A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. (2006) J Thromb Haemost. 4: 2616–22.
https://www.ncbi.nlm.nih.gov/pubmed/27525650

Associated Breed(s):

Australian Shepherd, Beagle, Giant Schnauzer, Japanese Spitz, Miniature Australian Shepherd, Miniature Schnauzer, Mixed Breed, Papillon, Scottish Deerhound, Toy Australian Shepherd,

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