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Increased Susceptibility to M. Avium Infection

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Test Overview:

Mycobacterium avium complex is a group of mycobacteria that could possibly contain pathogenic elements. Dogs are often exposed to this bacteria as it is commonly found in the environment like soil and water. Usually dogs are not at risk due to their natural resistant to the infection, however some dogs who have immune system defects may be susceptible to the infection. Therefore, genetic factors can determine the susceptibility to infection. Mycobacterium avium is life threatening and common signs can include enlarged lymph nodes, liver and spleen. Additionally, further symptoms includes vomitting, lethargy, weakness, anorexia, fever, runny rose, diarrhoea, blood in stool, conjunctivitis or respiratory issues.

Category:

Immunologic - Associated with the organs and cells of the immune system

Gene:

CARD9

Severity:

Severe. This disease has a high impact on affected animals, either with severe clinical signs causing significant suffering, or carrying a rapidly fatal course.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing can determine if a dog is a carrier for Increased Susceptibility to M. Avium Infection.

Research Citation(s):

Keijiro Mizukami, Angella Dorsey-Oresto, Karthik Raj, Anna Erings, Eva Furrow, Gary S. Johnsom, Urs Giger: A codon deletion in CARD9 gene causes increased susceptibility to Mycobacterium Avium complex in Miniature Schnauzer Dogs: The 9th international conference on canine and feline genetics and genomics

Associated Breed(s):

Miniature Schnauzer,

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