/ 0

Store

Haemophilia A (Rhodesian Ridgeback Type)

$50

(ONLINE PRICE)

ADD TO CART

Test Overview:

Genetic testing for the F8 gene SINE insertion is essential in Rhodesian Ridgebacks to identify carriers and affected dogs. Affected males (with mutation on their single X chromosome) should not be bred. Female carriers should only be bred to males clear of the mutation to avoid affected male offspring. Avoid mating two carriers to prevent affected offspring. Sharing genetic testing results supports responsible breeding decisions and reduces disease incidence.

Category:

Haemolymphatic - Associated with the blood and lymph

Gene:

F8

Variant Detected:

Chr X: c.4824_4825insN[221]

Severity:

Severe. This disease has a high impact on affected animals, either with severe clinical signs causing significant suffering, or carrying a rapidly fatal course.

Mode of Inheritance:

Autosomal X-Linked

Recommended Screening:

Genetic testing of the F8 gene will reliably determine if a dog is a genetic carrier of hemophilia A (Rhodesian Ridgeback Type).

Research Citation(s):

https://pubmed.ncbi.nlm.nih.gov/33494213/ Kehl A, Haaland AH, Langbein-Detsch I, Mueller E. A SINE Insertion in F8 Gene Leads to Severe Form of Hemophilia A in a Family of Rhodesian Ridgebacks. Genes (Basel). 2021 Jan 21;12(2):134. doi: 10.3390/genes12020134. [PubMed: 33494213]

Associated Breed(s):

Rhodesian Ridgeback ,

##parent-placeholder-19bd1503d9bad449304cc6b4e977b74bac6cc771##