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Haemophilia A (Rhodesian Ridgeback Type)

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Test Overview:

Hemophilia A (Rhodesian Ridgeback Type) affects dogs and is an inherited bleeding disorder. Haemophilia A (Rhodesian Ridgeback Type) disorder is caused by a deficiency of coagulation factor VIII. This is an essential protein needed for normal blood clotting. While there are some differences in bleeding tendency for this disease, at birth, Rhodesian ridgebacks may present with prolonged bleeding from the umbilical cord. As dogs with this disorder age, they may bruise easily, bleed from the mouth when juvenile teeth are lost, have frequent nose bleeds, or show signs of lameness or stiffness if bleeding occurs in the joints or muscle. After trauma or surgery, there is significant risk for prolonged bleeding, where the bleeding may be severe enough to be fatal. Veterinarians performing surgery on known affected dogs should have ready access to blood for transfusions.

Category:

Haemolymphatic - Associated with the blood and lymph

Gene:

F8

Variant Detected:

Chr X: c.4824_4825insN[221]

Severity:

Severe. This disease has a high impact on affected animals, either with severe clinical signs causing significant suffering, or carrying a rapidly fatal course.

Mode of Inheritance:

Autosomal X-Linked

Recommended Screening:

Genetic testing of the F8 gene will reliably determine if a dog is a genetic carrier of hemophilia A (Rhodesian Ridgeback Type).

Research Citation(s):

https://pubmed.ncbi.nlm.nih.gov/33494213/ Kehl A, Haaland AH, Langbein-Detsch I, Mueller E. A SINE Insertion in F8 Gene Leads to Severe Form of Hemophilia A in a Family of Rhodesian Ridgebacks. Genes (Basel). 2021 Jan 21;12(2):134. doi: 10.3390/genes12020134. [PubMed: 33494213]

Associated Breed(s):

Rhodesian Ridgeback ,

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