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Haemophilia B (Rhodesian Ridgeback Type)

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Test Overview:

Hemophilia B (Rhodesian ridgeback type) affects dogs and is an inherited bleeding disorder. This disorder is caused by a deficiency of coagulation factor IX, which is an essential protein needed for regular blood clotting. Between breeds, there are differences in the severity of the bleeding tendency with this disease. More severely affected dogs will present with severe bleeding after minor trauma or surgeries and occasionally exhibit spontaneous bleeding. Affected dogs may also bruise easily, have frequent nosebleeds, bleed from the mouth when juvenile teeth are lost, or show signs of lameness or stiffness if bleeding occurs in the joints or muscle. A mildly affected dog may present with easy and excessive bruising and frequent nosebleeds. However, there is a significant risk for prolonged bleeding after trauma or surgery, and in some instances, the bleeding may be severe enough to cause death. Veterinarians performing surgery on known affected dogs should have ready access to blood for transfusions. Most dogs will have a normal lifespan with this condition.

Category:

Haemolymphatic - Associated with the blood and lymph

Gene:

F9

Variant Detected:

chrX:109530868 (canFam3): G>A

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal X-Linked

Recommended Screening:

Genetic testing of the F9 gene will reliably determine if a dog is a genetic carrier of hemophilia B (Rhodesian ridgeback type).

Research Citation(s):

https://pubmed.ncbi.nlm.nih.gov/20303304/ Mischke R, Kühnlein P, Kehl A, Langbein-Detsch I, Steudle F, Schmid A, Dandekar T, Czwalinna A, Müller E. G244E in the canine factor IX gene leads to severe haemophilia B in Rhodesian Ridgebacks. Vet J. 2011 Jan; 187(1):113-8. [PubMed: 20303304]

Associated Breed(s):

Rhodesian Ridgeback ,

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