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Haemophilia B (Rhodesian Ridgeback Type)

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Test Overview:

Genetic testing for the F9 exon 7 missense mutation is crucial among Rhodesian Ridgebacks to identify carriers and affected dogs. Affected males should not be bred. Female carriers should be bred only to clear males to avoid affected male offspring. Avoid mating two carriers due to 25% risk of affected pups. Sharing genetic results supports responsible breeding to reduce disease prevalence.

Category:

Haemolymphatic - Associated with the blood and lymph

Gene:

F9

Variant Detected:

c.731G>A in exon 7

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal X-Linked

Recommended Screening:

Genetic testing of the F9 gene will reliably determine if a dog is a genetic carrier of hemophilia B (Rhodesian ridgeback type).

Research Citation(s):

https://pubmed.ncbi.nlm.nih.gov/20303304/ Mischke R, Kühnlein P, Kehl A, Langbein-Detsch I, Steudle F, Schmid A, Dandekar T, Czwalinna A, Müller E. G244E in the canine factor IX gene leads to severe haemophilia B in Rhodesian Ridgebacks. Vet J. 2011 Jan; 187(1):113-8. [PubMed: 20303304]

Associated Breed(s):

Rhodesian Ridgeback ,

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