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Early Onset Adult Deafness (Rhodesian Ridgeback)

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Test Overview:

Genetic testing of breeding dogs is crucial to identify carriers. Avoid mating two carriers to prevent producing affected puppies. Carrier dogs can be bred to clear (non-carrier) dogs, but offspring should be tested before breeding. Responsible breeding programs can reduce disease prevalence over time.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

EPS8L2

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the EPS8L2 gene will reliably determine if a dog is a genetic carrier of Early Onset Adult Deafness. Confirmation of deafness is usually confirmed via BAER test.

Research Citation(s):

awakami T, Raghavan V, Ruhe AL, Jensen MK, Milano A, Nelson TC, Boyko AR. Early onset adult deafness in the Rhodesian Ridgeback dog is associated with an in-frame deletion in the EPS8L2 gene. PLoS One. 2022 Apr 6;17(4):e0264365. [PubMed: 35385474] Strain GM. The Genetics of Deafness in Domestic Animals. Front Vet Sci. 2015 Sep 8;2:29. doi: 10.3389/fvets.2015.00029. [PubMed: 26664958]

Associated Breed(s):

Rhodesian Ridgeback ,

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