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Gastrointestinal Polyposis

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Test Overview:

Due to the autosomal dominant inheritance and health impact, genetic testing for the APC mutation is strongly advised in predisposed breeds such as the Jack Russell Terrier. Breeders should avoid breeding affected or carrier animals when possible to reduce disease prevalence. Early detection and diagnosis also aid in clinical management and prolonging survival

Category:

Digestive system / Gastrointestinal - Associated with the organs and structures of the digestive system

Gene:

APC

Variant Detected:

c.[462_463delinsTT]

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Autosomal Dominant

Recommended Screening:

Genetic testing of the APC gene will reliably determine if a dog is a genetic carrier of Gastrointestinal Polyposis. Screening tests: Endoscopy (examination of the stomach and intestines can detect polyps), Ultrasound (can be used to visualise polyps) and Biopsy (a tissue sample from a polyp can be examined under a microscope to determine if it is malignant or benign).

Research Citation(s):

https://pubmed.ncbi.nlm.nih.gov/37505844/

Associated Breed(s):

Jack Russell Terrier,

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