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Ichthyosis (Jack Russell Terrier Type)

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Test Overview:

Ichthyosis (Jack Russell Terrier Type) affects dogs and is an inherited condition of the skin. This disorder is characterised by parchment like scaling of the skin generalised over the whole body, but easily visible in the non or lightly haired regions of the abdomen. Present from birth, scaling skin can persist into adulthood and may result in secondary infections including ear infections. The pads of the dogs feet may also show signs of skin overgrowth and nails may be soft. Ichthyosis (Jack Russell Terrier Type) does not typically cause hair loss. Treatment for this condition focuses on reducing complications and improving the health of the skin through oral and topical medications.

Category:

Dermatologic - Associated with the skin

Gene:

TGM1

Variant Detected:

chr8:4236320-4236321 (canFam3): 1980 bp insertion + 14 bp flanking dup(AAAGATCCAAGGAG)

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the TGM1 gene will reliably determine if a dog is a genetic carrier of Ichthyosis (Jack Russell Terrier Type).

Research Citation(s):

Credille KM, Minor JS, Barnhart KF, Lee E, Cox ML, Tucker KA, Diegel KL, Venta PJ, Hohl D, Huber M, Dunstan RW. Transglutaminase 1-deficient recessive lamellar ichthyosis associated with a LINE-1 insertion in Jack Russell terrier dogs. Br J Dermatol. 2009 Aug;161(2):265-72. Epub 2009 Apr 24. [PubMed: 19438474] Lewis, Ford, Kwochka. Characterization and management of a Jack Russell terrier with congenital ichthyosis. Vet Dermatol. 1998 Jun;9(2):111-118. [PubMed: 34645016]

Associated Breed(s):

Jack Russell Terrier,

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