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Amelogenesis Imperfecta (Samoyed Type) - SINGLE ASSAY TEST

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Test Overview:

Amelogenesis Imperfecta (Samoyed Type) is an inherited dental disorder affecting dogs. Affected dogs have abnormal or badly discolored teeth with irregular tooth surfaces. The deciduous or puppy teeth of these dogs are normal, but abnormalities are apparent upon eruption of the adult teeth. The teeth are often blunted with increased space between teeth due to thinning of the enamel layer. These dogs are predisposed to dental disease and subsequent advanced periodontal disease and bad breath. Tooth loss can occur due to severe abrasions, fractures, and tooth root infections.

Category:

Dental - Associated with the teeth and associated structures

Gene:

SLC24A4

Variant Detected:

chr8:1679118-1679119 (canFam3): 21 bp insertion

Severity:

Low. This disease generally causes mild signs of disease, or can be quite easily treated/managed.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Pedersen NC, Shope B, Liu H. An autosomal recessive mutation in SCL24A4 causing enamel hypoplasia in Samoyed and its relationship to breed-wide genetic diversity. Canine Genet Epidemiol. 2017 Nov 22;4:11. [PubMed: 29201383]

Associated Breed(s):

Samoyed,

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