L Locus (Long Hair/Fluffy) - Lh3 (Eurasier Breed Type)

Category:

Trait (Associated with Phenotype)

Gene:

FGF5

Variant Detected:

Lh3 = c.16 bp deletion; g.chr32:c.556_571del16 (Eurasier type)

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the FGF5 gene will reliably determine if a dog is a genetic carrier of long hair.

Research Citation(s):

https://pubmed.ncbi.nlm.nih.gov/23384345/ Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, VonHoldt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, Andre C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA. Coat variation in the domestic dog is governed by variants in three genes. Science. 2009 Oct; 326(5949):150-3. [PubMed: 19713490] Dierks C, Momke S, Philipp U, Distl O. Allelic heterogeneity of FGF5 mutations causes the long-hair phenotype in dogs. Anim Genet. 2013 Aug; 44(4):425-31. [PubMed: 23384345] Housley DJ, Venta PJ. The long and short of it: evidence that FGF5 is a major determinant of canine ‘hair’-itability. Anim Genet. 2006 Aug; 37(4):309-15. [PubMed: 16879338]

Associated Breed(s):

Chow Chow, Keeshond, Samoyed,