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Dandy Walker Like Malformation (Eurasier Breed Type)

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Test Overview:

Dandy Walker Like Malformation affects dogs and is an inherited neurological disease. Dogs affected by this disease begin walking with non-progressive signs of neurological disfunction that is caused by the underdevelopment of the Cerebellum in the brain. The cerebellum is crucial for coordinated movement. Signs of this disease include reduced or absent reflexes, tremors, involuntary abnormal eye movements, subtle high-stepping gait, and leaning or rolling to one side. Behaviour or ability to learn are not impaired or affected by this disease.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

VLDLR

Variant Detected:

deletion c.1713del/p.(W572Gfs*10) chr1

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

https://pubmed.ncbi.nlm.nih.gov/25668516/ Bernardino F, Rentmeister K, Schmidt MJ, Bruehschwein A, Matiasek K, Matiasek LA, Lauda A, Schoon HA, Fischer A. Inferior Cerebellar Hypoplasia Resembling a Dandy-Walker-Like Malformation in Purebred Eurasier Dogs with Familial Non-Progressive Ataxia: A Retrospective and Prospective Clinical Cohort Study. PLoS One. 2015 Feb 10;10(2):e0117670. doi: 10.1371/journal.pone.0117670. [PubMed: 25668516] Gerber M, Fischer A, Jagannathan V, Drogemuller M, Drogemuller C, Schmidt MJ, Bernardino F, Manz E, Matiasek K, Rentmeister K, Leeb T. A Deletion in the VLDLR Gene in Eurasier Dogs with Cerebellar Hypoplasia Resembling a Dandy-Walker-Like Malformation (DWLM). PLoS One. 2015 Feb 10;10(2):e0108917. doi: 10.1371/journal.pone.0108917. [PubMed: 25668033]

Associated Breed(s):

Chow Chow, Keeshond, Samoyed,

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