/ 0

Store

Dandy Walker Like Malformation (Eurasier Breed Type)

$50

(ONLINE PRICE)

ADD TO CART

Test Overview:

Breeding two carriers should be avoided to prevent affected offspring. Use genetic testing in breeding programs to identify carriers and manage mating decisions responsibly. This reduces the prevalence of DWLM and improves breed health over time.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

VLDLR

Variant Detected:

deletion c.1713del/p.(W572Gfs*10) chr1

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the VLDLR gene will reliably determine if a dog is a genetic carrier of Dandy-Walker-like malformation

Research Citation(s):

https://pubmed.ncbi.nlm.nih.gov/25668516/ Bernardino F, Rentmeister K, Schmidt MJ, Bruehschwein A, Matiasek K, Matiasek LA, Lauda A, Schoon HA, Fischer A. Inferior Cerebellar Hypoplasia Resembling a Dandy-Walker-Like Malformation in Purebred Eurasier Dogs with Familial Non-Progressive Ataxia: A Retrospective and Prospective Clinical Cohort Study. PLoS One. 2015 Feb 10;10(2):e0117670. doi: 10.1371/journal.pone.0117670. [PubMed: 25668516] Gerber M, Fischer A, Jagannathan V, Drogemuller M, Drogemuller C, Schmidt MJ, Bernardino F, Manz E, Matiasek K, Rentmeister K, Leeb T. A Deletion in the VLDLR Gene in Eurasier Dogs with Cerebellar Hypoplasia Resembling a Dandy-Walker-Like Malformation (DWLM). PLoS One. 2015 Feb 10;10(2):e0108917. doi: 10.1371/journal.pone.0108917. [PubMed: 25668033]

Associated Breed(s):

Chow Chow, Keeshond, Samoyed,

##parent-placeholder-e7e0bb492b2b733049d7814542aa1796cd44b9b6##