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Cystinuria (SLC3A1) (Australian Cattle Dog Type)

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Test Overview:

Breeders should avoid mating two affected dogs to prevent producing offspring with severe cystinuria. Genetic screening prior to breeding is highly recommended to reduce the frequency of the mutation in the population while maintaining breed diversity. Responsible breeding includes selection of mates to avoid homozygous offspring and reduce clinical disease incidence.

Category:

Urinary system / Urologic - Associated with the kidneys, bladder, ureters and urethra

Gene:

Solute carrier family 3 member 1 (SLC3A1) on chromosome 10

Variant Detected:

c.1095_1100delACCACC

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Dominant with Incomplete Penetrance

Recommended Screening:

Breeding animals should be screened prior to entering into breeding programs. Genetic testing of the SLC3A1 gene will reliably determine if a dog is a genetic carrier of cystinuria (Australian cattle dog type).

Research Citation(s):

Brons AK, et al. SLC3A1 and SLC7A9 Mutations in Autosomal Recessive or Dominant Canine Cystinuria: A New Classification System. (2013) J vet intern med, 27(6);1400-1408

Associated Breed(s):

Australian Cattle Dog, Border Collie, Koolie , Mixed Breed, Smithfield,

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