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Body Size IGSF1 "Bulky Gene"

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Test Overview:

Breeding large dogs with IGSF1 variants should be planned carefully to manage health risks associated with large size (e.g., orthopedic issues). Genetic knowledge can reduce unexpected size extremes in litters and support selection for size-appropriate traits. There are currently no specific recommendations to avoid IGSF1 variants as they relate to disease but rather to monitor size-associated health risks.

Category:

Trait (Associated with Phenotype)

Gene:

IGSF1

Variant Detected:

chrX.g.102369488-102369489insAAC, p.Asp376_Glu377insAsn, Chromosome X

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Plassais, 2017, PLoS Genet 13(3): e1006661

Associated Breed(s):

American Bulldog , American Bully (Micro/Pocket/Classic/XL), American Staffordshire Terrier, Australian Stumpy Tail Cattle Dog, Border Collie, British Bulldog, Cavoodle, Finnish Lapphund, French Bulldog, Groodle, Peruvian Hairless Dog, Southern Cross Bulldog, Staffordshire Bull Terrier , White Swiss Shepherd,
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