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Goniodysgenesis and Glaucoma (Border Collie)

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Test Overview:

Genetic testing for the OLFML3 mutation is recommended for Border Collie breeders to identify carriers and affected dogs. Avoid breeding two carriers to reduce risk of producing affected puppies with severe goniodysgenesis and glaucoma. Testing combined with clinical eye examinations (gonioscopy) aids in making informed breeding decisions. Continuing pedigree analysis helps reduce disease frequency and avoid popular sires contributing to the mutation. Responsible breeding can decrease the incidence and severity of this eye disorder in the population.

Category:

Ophthalmologic - Associated with the eyes and associated structures

Gene:

OLFML3

Variant Detected:

c.590G>A

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the OLFML3 gene will reliably determine if a dog is a genetic carrier of Goniodysgenesis and Glaucoma (Border Collie).

Research Citation(s):

Gelatt KN, (2004.): Prevalence of the breed-related glaucomas in pure-bred dogs in North America. Vet Ophthalmol. 2004;7:97–111. Carys A Pugh, Lindsay L Farrell, Ailsa J Carlisle, Stephen J Bush, Violeta Trejo-Reveles, Oswald Matika, Arne de Kloet, Caitlin Walsh, Stephen C Bishop, James GD Prendergast, Jeffrey J Schoenebeck, Joe Rainger, Kim M Summers: Arginine to glutamine mutation in olfactomedin-like 3 (OLFML3) is a candidate for severe goniodysgenesis and glaucoma in the Border Collie dog breed. doi: https://doi.org/10.1101/321406

Associated Breed(s):

Border Collie, Koolie , Mixed Breed,

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