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Xanthine Urolithiasis (Manchester Terrier Type)

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Test Overview:

Xanthine Urolithiasis is a disorder that is characterised by the excretion of large quantities of xanthine in the urine. The enzyme that normally converts xanthine to uric acid is damaged. Therefore, xanthine results from low solubility, and it precipitates easily forming xanthine stones. These xanthine stones can irritate the urinary tract, increases urinary tract infection susceptibility, cause urination stagnation and can lead to secondary kidney damage.

Category:

Urogenital (Associated with the Urinary and Genital Tracts)

Gene:

MOCOS

Variant Detected:

c.232G>T

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing can determine if a dog is a carrier for Xanthine Urolithiasis.

Research Citation(s):

Tate, N.M., Minor, K.M., Lulich, J.P., Mickelson, J.R., Berent, A., Foster, J.D., Petersen, K.H., Furrow, E. : Multiple variants in XDH and MOCOS underlie xanthine urolithiasis in dogs. Mol Genet Metab Rep 29:100792, 2021. Pubmed reference: 34584846

Associated Breed(s):

Manchester Terrier , Toy Manchester Terrier,

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