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Haemophilia B (Lhasa Apso Type)

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Test Overview:

Haemophilia B is a clotting disorder and occurs due to a deficiency of an essential clotting factor in the blood (clotting factor IX). This disease is inherited (recessively) on the X chromosome, and hence is seen in male animals (who only have one copy of the X chromosome). Haemophilia B is also sometimes called Christmas disease. It is similar to haemophilia A, but in general causes less severe bleeding.

Category:

Haemolymphatic - Associated with the blood and lymph

Gene:

F9

Variant Detected:

F9_356_Del

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal X-Linked

Research Citation(s):

Dodds WJ. Current Concepts of Hereditary Coagulation Disorders in Dogs. Experimentation Animale. 1969;1:243. [Not In PubMed] Mauser AE, Whitlark J, Whitney KM, Lothrop CD Jr. A deletion mutation causes hemophilia B in Lhasa Apso dogs. Blood. 1996 Nov 1;88(9):3451-5. [PubMed: 8896410] Nichols TC, Dillow AM, Franck HW, Merricks EP, Raymer RA, Bellinger DA, Arruda VR, High KA. Protein replacement therapy and gene transfer in canine models of hemophilia A, hemophilia B, von willebrand disease, and factor VII deficiency. ILAR J. 2009;50(2):144-67. [PubMed: 19293459]

Associated Breed(s):

Lhasa Apso,

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