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Haemophilia B (Lhasa Apso Type)

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Test Overview:

Genetic testing for the F9 gene mutation is recommended in Lhasa Apso dogs to identify carriers and affected individuals. Male dogs with the mutation should not be bred. Female carriers should only be bred to clear males to avoid affected male puppies. Avoid mating two carriers to reduce disease incidence. Sharing test results helps responsible breeding and disease control.

Category:

Haemolymphatic - Associated with the blood and lymph

Gene:

F9

Variant Detected:

deletion of nucleotides 772-776 plus a C>T transition at nucleotide 777

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal X-Linked

Recommended Screening:

Genetic testing of the F9 gene will reliably determine if a dog is a genetic carrier of haemophilia B (Lhasa apso type).

Research Citation(s):

Dodds WJ. Current Concepts of Hereditary Coagulation Disorders in Dogs. Experimentation Animale. 1969;1:243. [Not In PubMed] Mauser AE, Whitlark J, Whitney KM, Lothrop CD Jr. A deletion mutation causes hemophilia B in Lhasa Apso dogs. Blood. 1996 Nov 1;88(9):3451-5. [PubMed: 8896410] Nichols TC, Dillow AM, Franck HW, Merricks EP, Raymer RA, Bellinger DA, Arruda VR, High KA. Protein replacement therapy and gene transfer in canine models of hemophilia A, hemophilia B, von willebrand disease, and factor VII deficiency. ILAR J. 2009;50(2):144-67. [PubMed: 19293459]

Associated Breed(s):

Lhasa Apso,

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