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Airway Distress Syndrome (ADAMTS3) - Risk Marker

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Test Overview:

Do not breed affected dogs homozygous for the ADAMTS3 mutation, as they are likely to develop airway disease. Avoid carrier (heterozygous) × carrier matings, which give a 25% chance of producing affected puppies per litter. Breed carriers only to clear (non-carrier) dogs to prevent affected offspring, although some puppies will be carriers. Routine genetic screening is recommended for breeds known to carry the ADAMTS3 mutation—especially French Bulldogs, English Bulldogs, Norwich Terriers, and Pugs. Breeders should use results of testing alongside clinical assessments to implement breeding practices that reduce airway disease while maintaining genetic diversity.

Category:

Respiratory - Associated with the lungs and respiratory system

Gene:

ADAMTS3

Variant Detected:

c.2786G>A

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008102 https://pubmed.ncbi.nlm.nih.gov/31095560/ https://www.researchgate.net/publication/333151249_An_ADAMTS3_missense_variant_is_associated_with_Norwich_Terrier_upper_airway_syndrome

Associated Breed(s):

Boston Terrier, Boxer , British Bulldog, Bullmastiff, Cairn Terrier, Cavalier King Charles Spaniel, French Bulldog, Griffon Bruxellois - Standard, Lhasa Apso, Maltese Shih tzu, Mastiff , Norwich Terrier, Pekingese, Pug, Pugalier, Shar Pei, Shih tzu,

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