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Cystinuria (SLC3A1) Labrador Retriever Type

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Test Overview:

Breeders should avoid mating two carriers to prevent producing affected offspring. Genetic screening prior to breeding is strongly recommended in breeds where this mutation is present. Responsible breeding programs aim to decrease the disease prevalence while maintaining genetic diversity.

Category:

Urinary system / Urologic - Associated with the kidneys, bladder, ureters and urethra

Gene:

Solute carrier family 3 member 1 (SLC3A1) on chromosome 10

Variant Detected:

c.350delG located in exon 1

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Breeding animals should be screened prior to entering into breeding programs.

Research Citation(s):

Brons AK, et al. SLC3A1 and SLC7A9 Mutations in Autosomal Recessive or Dominant Canine Cystinuria: A New Classification System. (2013) J vet intern med, 27(6);1400-1408

Associated Breed(s):

Australian Labradoodle , Cavador, Labradoodle , Labradoodle Retrodoodle , Labrador Retriever,

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