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Hereditary Nasal Parakeratosis/Dry Nose (Labrador Retriever Type)

Hereditary Nasal Parakeratosis/Dry Nose (Labrador Retriever Type)

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Test Overview:

Also referred to as Hereditary Nasal Parakeratosis (HNPK). Affected dogs begin showing clinical signs around six to twelve months of age. They develop dry, rough crusts on the tip of the nose. In extreme cases, the dog’s nose will crack causing severe discomfort. Lesions can occur on the area around the nose. The noses of these affected dogs are prone to bacterial infections and can lose pigment over time. This disorder may be treated with veterinary consultation and topical therapy.

Category:

Dermatologic - Associated with the skin

Gene:

Suppressor of variegation 3-9 homolog 2 (SUV39H2) on chromosome 2

Variant Detected:

Base Substitution c.972T>G p.Asn324Lys chr2:21731842 (canFam3): T>G

Severity:

Low. This disease generally causes mild signs of disease, or can be quite easily treated/managed.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the SUV39H2 gene in Labrador Retrievers will reliably determine if a dog is a genetic carrier of hereditary nasal parakeratosis.

Research Citation(s):

Jagannathan V, et al. A mutation in the SUV39H2 gene in Labrador Retrievers with hereditary nasal parakeratosis (HNPK) provides insights into the epigenetics of keratinocyte differentiation. (2013) PLoS Genet, 9;10,e1003848. Jagannathan V, Bannoehr J, Plattet P, Hauswirth R, Drogemuller C, Drogemuller M, Weiner DJ, Doherr M, Owczarek-Lipska M, Galichet A, Welle MM, Tengvall K, Bergvall K, Lohi H, Rufenacht S, Linek M, Paradis M, Muller EJ, Roosje P, Leeb T. A mutation in the SUV39H2 gene in Labrador retrievers with hereditary nasal parakeratosis (HNPK) provides insights into the epigenetics of keratinocyte differentiation. PLoS Genet. 2013;9(10):e1003848. doi: 10.1371/journal.pgen.1003848. Epub 2013 Oct 3. [PubMed: 24098150] Page N, Paradis M, Lapointe JM, Dunstan RW. Hereditary nasal parakeratosis in Labrador Retrievers. Vet Dermatol. 2003 Apr;14(2):103-10. [PubMed: 12662268]

Associated Breed(s):

Australian Cobberdog, Australian Labradoodle , Goldendoodle, Labradoodle , Labradoodle Retrodoodle , Labrador Retriever, Mixed Breed,

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