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Congenital Deafness (Australian Stumply Tail Cattle Dog Type) (LINKAGE CANDIDATE GENE)

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Test Overview:

Genetic Testing and Hearing Screening: Use Brainstem Auditory Evoked Response (BAER) testing to screen all puppies between 6-8 weeks of age to identify hearing status early. This helps differentiate between deaf and hearing puppies before they go to new homes. Avoid Breeding Two Carriers: Since congenital deafness in Australian Stumpy Tail Cattle Dogs is inherited as an autosomal recessive trait, avoid breeding two dogs that are carriers or both deaf to prevent producing affected puppies. Select Breeding Pairs Carefully: Breed carrier dogs only to clear dogs (non-carriers) to ensure no puppies are born deaf, though some may be carriers. Avoid Selection Based on Coat Color Alone: Unlike some breeds, deafness in ASCD is not clearly associated with white or merle coat patterns, so breeding decisions should rely primarily on hearing and genetic testing rather than coat color. Keep Records and Share Information: Maintain detailed health and genetic records for breeders and owners, and share information about deafness status for transparency and improved breed health. Consider Genetic Research Developments: Stay updated on genetic markers like the candidate gene KLF7, as future DNA tests may become available to assist in identifying carriers reliably.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

KLF7

Variant Detected:

g.15562684G>A chr37

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive with Incomplete Penetrance

Research Citation(s):

https://pubmed.ncbi.nlm.nih.gov/33805165/

Associated Breed(s):

Australian Cattle Dog, Australian Stumpy Tail Cattle Dog,

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