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Canine Leukocyte Adhesion Deficiency Type III (German Shepherd Type)

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Test Overview:

Leukocyte adhesion deficiency type III is an inherited blood disorder affecting dogs. Affected dogs have abnormal platelet and white blood cell activity resulting in abnormal blood clotting and immune system function. Dogs may present with lameness, prolonged bleeding and recurrent, chronic infections especially of the skin and gums and often accompanied by fever. Other symptoms include persistently elevated white blood cell counts (leukocytosis). Dogs can live for years with this condition although they are susceptible to life-threatening bleeding with an accidental injury or any surgical procedure. Veterinarians performing surgery on known affected dogs should have ready access to blood banked for transfusions.

Category:

Immunologic - Associated with the organs and cells of the immune system

Gene:

FERMT3

Variant Detected:

chr18:52835932-52835933 (canFam3): 12 bp insertion (ins AAGACGGCTGCC)

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

2014 Hugo, T.B., Heading, K.L. : Leucocyte adhesion deficiency III in a mixed-breed dog. Aust Vet J 92:299-302, 2014. Pubmed reference: 24954630. DOI: 10.1111/avj.12206.
Boudreaux MK, Wardrop KJ, Kiklevich V, Felsburg P, Snekvik K. A mutation in the canine Kindlin-3 gene associated with increased bleeding risk and susceptibility to infections. Thromb Haemost. 2010 Feb; 103(2):475-7. [PubMed: 20126836]571.

Associated Breed(s):

German Shepherd Dog, Mixed Breed, White Swiss Shepherd,

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