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Canine Leukocyte Adhesion Deficiency Type III (German Shepherd Type)

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Test Overview:

Do not breed affected dogs homozygous for the FERMT3 mutation. Avoid carrier × carrier matings as they have a 25% chance of producing affected puppies. Breed carriers only to dogs clear of the mutation to eliminate risk of affected puppies while maintaining genetic diversity. Routine genetic screening in German Shepherd breeding programs is strongly recommended to reduce disease incidence.

Category:

Immunologic - Associated with the organs and cells of the immune system

Gene:

FERMT3

Variant Detected:

c.1349_1350insAAGACGGCTGCC

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

2014 Hugo, T.B., Heading, K.L. : Leucocyte adhesion deficiency III in a mixed-breed dog. Aust Vet J 92:299-302, 2014. Pubmed reference: 24954630. DOI: 10.1111/avj.12206.
Boudreaux MK, Wardrop KJ, Kiklevich V, Felsburg P, Snekvik K. A mutation in the canine Kindlin-3 gene associated with increased bleeding risk and susceptibility to infections. Thromb Haemost. 2010 Feb; 103(2):475-7. [PubMed: 20126836]571.

Associated Breed(s):

German Shepherd Dog, Mixed Breed, White Swiss Shepherd,

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