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Beta Mannisidosis (German Shepherd Type)

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Test Overview:

Do not breed affected dogs that are homozygous for the MANBA mutation. Avoid carrier × carrier matings, which have a 25% risk of affected offspring. Breed carriers only to genetically clear (non-carrier) dogs to prevent affected puppies though some carriers will result. Routine genetic screening of breeding stock is strongly advised in German Shepherd breeding programs to reduce disease incidence while maintaining genetic diversity.

Category:

Metabolic - Associated with the enzymes and metabolic processes of cells

Gene:

MANBA

Variant Detected:

c.560T>A in exon 4

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Associated Breed(s):

German Shepherd Dog,

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