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Recurrent Inflammatory Pulmonary (Collie Type)

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Test Overview:

Recurrent Inflammatory Pulmonary disease affects dogs and is an inherited disease. Dogs affected with this disease present with signs of respiratory disease including coughing, nasal discharge, fever, vomiting, and shallow, noisy breathing within the first week of life. Dogs do respond to treatment, but relapse quickly after treatment has ended. Some dogs may be maintained with medical therapy for years while continuing to have signs of respiratory disease throughout their life.

Category:

Respiratory - Associated with the lungs and respiratory system

Gene:

AKNA on Chr 11

Variant Detected:

chr11:68576237-68576240: 4 bp deletion (del ACAG)

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the AKNA gene will reliably determine if a dog is a genetic carrier of Recurrent Inflammatory Pulmonary disease.

Research Citation(s):

Hug P, Anderegg L, Kehl A, Jagannathan V, Leeb T. AKNA Frameshift Variant in Three Dogs with Recurrent Inflammatory Pulmonary Disease. Genes (Basel). 2019 Jul 26;10(8). pii: E567. [PubMed: 31357536]

Associated Breed(s):

Collie Rough, Collie Smooth,

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