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Nonsyndromic Hearing Loss

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Test Overview:

Nonsyndromic Hearing Loss affects dogs and is an early-onset, inherited hearing disorder. Affected dogs may present with hearing deficits during the first weeks of life. By 4 months of age, deafness can be diagnosed by a veterinarian using an brainstem auditory evoked response (BAER) testing. There are no other clinical abnormalities in affected dogs, and they live otherwise normal lives.

Category:

Ontogeny / ontogenesis (or simply developmental) - Developmental (Diseases associated with in-utero development)

Gene:

LOXHD1

Variant Detected:

chr7:44796966 (canFam4): G/C

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the LOXHD1 gene will reliably determine if a dog is a genetic carrier of Nonsyndromic Hearing Loss.

Research Citation(s):

Hytonen MK, Niskanen JE, Arumilli M, Brookhart-Knox CA, Donner J, Lohi H. Missense variant in LOXHD1 is associated with canine nonsyndromic hearing loss. Hum Genet. 2021 Nov;140(11):1611-1618. [PubMed: 33983508]

Associated Breed(s):

Mixed Breed, Rottweiler ,

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