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Footpad Hyperkeratosis (Rottweiler)

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Category:

Dermatologic - Associated with the skin

Gene:

DSG1, chr7

Variant Detected:

c.2541_2545delGGGCT p.Gly848Trpfs*2

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the DSG1 gene will reliably determine if a dog is a genetic carrier of Hereditary Footpad Hyperkeratosis (Rottweiler Type).

Research Citation(s):

Backel KA, Kiener S, Jagannathan V, Casal ML, Leeb T, Mauldin EA. A DSG1 Frameshift Variant in a Rottweiler Dog with Footpad Hyperkeratosis. Genes (Basel). 2020 Apr 24;11(4):469. [PubMed: 32344723]

Associated Breed(s):

Rottweiler ,

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