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Narcolepsy (Dachshund Type)

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Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

HCRTR2

Variant Detected:

c.160G>A chr12:22517939 (canFam3): G>A

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the HCRTR2 gene will reliably determine if a dog is a genetic carrier of narcolepsy (dachshund type).

Research Citation(s):

Genome Res. 2001 Apr;11(4):531-9 Chen L, Brown RE, McKenna JT, McCarley RW. Animal models of narcolepsy. CNS Neurol Disord Drug Targets. 2009 Aug;8(4):296-308. [PubMed: 19689311] Hungs M, Fan J, Lin L, Lin X, Maki RA, Mignot E. Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines. Genome Res. 2001 Apr; 11(4):531-9. [PubMed: 11282968]

Associated Breed(s):

Dachshund , Dachshund Short Hair, Dachshund Standard Long Hair, Dachshund Standard Smooth Hair, Dachshund Standard Wire Hair, Dachshund Wire Hair, Miniature Dachshund, Miniature Dachshund Long Hair, Miniature Dachshund Short Hair, Miniature Dachshund Smooth Hair, Miniature Dachshund Wire Hair,
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