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Ectodermal Dysplasia, X-Linked (Dachshund Type)

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Test Overview:

X-linked Ectodermal Dysplasia affects dogs and is an inherited disease. Dogs affected by this disease are born with symmetrical hairlessness of variable severity on their head, lower chest, lower back, abdomen, and inner part of the limbs closest to the body. Abnormal or missing sweat glands are usual and affected dogs often have missing teeth or display abnormal spacing between their teeth. Dogs frequently show chronic nasal discharge and are more prone to respiratory and skin infections. These infections may therefore be severe enough to cause fatality or require euthanasia

Category:

Dermatologic - Associated with the skin

Gene:

EDA

Variant Detected:

chrX:54509504 (canFam3): 1 bp deletion (del T)

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal X-Linked

Recommended Screening:

Genetic testing of the EDA gene will reliably determine if a dog is a genetic carrier of X-linked ectodermal dysplasia.

Research Citation(s):

https://pubmed.ncbi.nlm.nih.gov/30397018/ Vasiliadis D, Hewicker-Trautwein M, Klotz D, Fehr M, Ruseva S, Arndt J, Metzger J, Distl O. A de novo EDA-variant in a litter of shorthaired standard Dachshunds with X-linked hypohidrotic ectodermal dysplasia. G3: Genes, Genomes, Genetics January 1, 2019 vol. 9 no. 1 95-104; https://doi.org/10.1534/g3.118.200814 [Not in PubMed]

Associated Breed(s):

Dachshund , Dachshund Short Hair, Dachshund Standard Long Hair, Dachshund Standard Smooth Hair, Dachshund Standard Wire Hair, Dachshund Wire Hair, Kaninchen Dachshund, Miniature Dachshund, Miniature Dachshund Long Hair, Miniature Dachshund Short Hair, Miniature Dachshund Smooth Hair, Miniature Dachshund Wire Hair,

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