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Hereditary Nasal Parakeratosis (Greyhound Type)

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Test Overview:

Hereditary nasal parakeratosis (greyhound type) affects dogs and is an inherited skin disease. Affected dogs (as puppies) will present with dry, rough, grey to brown crusts and rarely, painful cracks on the tip of the nose. The noses of affected dogs are prone to superficial bacterial infections and often become depigmented over time, however, affected dogs are otherwise healthy. Symptoms often change and differ in severity over the dog’s life. Although this disease is manageable, it does require continuous topical therapy to prevent recurrence of excessive nasal crusting.

Category:

Dermatologic - Associated with the skin

Gene:

HNPK

Variant Detected:

chr2:21731812-21731815 (canFam3): 4 bp deletion (del AAGT)

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the SUV39H2 gene will reliably determine if a dog is a genetic carrier of hereditary nasal parakeratosis (greyhound type).

Research Citation(s):

Bannoehr J, Balmer P, Stoffel MH, Jagannathan V, Gaschen V, Kühni K, Sayar B, Drögemüller M, Howald D, Wiener DJ, Leeb T, Welle MM, Müller EJ, Roosje PJ. Abnormal keratinocyte differentiation in the nasal planum of Labrador Retrievers with hereditary nasal parakeratosis (HNPK). PLoS One. 2020 Mar 2;15(3):e0225901. doi: 10.1371/journal.pone.0225901. [PubMed: 32119674] Bauer A, Nimmo J, Newman R, Brunner M, Welle MM, Jagannathan V, Leeb T. A splice site variant in the SUV39H2 gene in Greyhounds with nasal parakeratosis. Anim Genet. 2018 Apr;49(2):137-140. doi: 10.1111/age.12643. [PubMed: 29423952]

Associated Breed(s):

Greyhound ,

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