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Glomerulopathy (PLN) KIRREL2

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Test Overview:

Due to complex inheritance, genetic testing is helpful but not definitively predictive. Breeding decisions should consider testing for KIRREL2 and NPHS1 variants, especially in predisposed breeds like Soft Coated Wheaten Terrier, Airedale Terrier, and Danish-Swedish Farmdog. Avoid breeding carriers together to reduce risk of affected offspring. Monitor dogs for early signs of PLN via veterinary screening including urinalysis and blood work.

Category:

Urinary system / Urologic - Associated with the kidneys, bladder, ureters and urethra

Gene:

KIRREL2

Variant Detected:

K2:c.1877C>G

Severity:

Severe. This disease has a high impact on affected animals, either with severe clinical signs causing significant suffering, or carrying a rapidly fatal course.

Mode of Inheritance:

Complex - Mode Unknown

Recommended Screening:

Genetic testing of the KIRREL2 gene will reliably determine if a dog is a genetic carrier of Glomerulopathy.

Research Citation(s):

Mamm Genome (2013) 24(3-4):119–126

Associated Breed(s):

Airedale Terrier, Mixed Breed, Soft Coated Wheaten Terrier,

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