/ 0

Store

Fatal Neonatal Interstitial Lung Disease (LAMP)

$50

(ONLINE PRICE)

ADD TO CART

Test Overview:

Affected individuals and carriers should be excluded from breeding programs. Genetic screening is recommended where mutations are known, to prevent propagation of lethal alleles and future generations suffering from untreatable disease. For humans, affected families should be offered genetic counselling to assess recurrence risk and discuss reproductive options

Category:

Cardiorespiratory (Associated with Heart and Lungs)

Gene:

LAMP3

Variant Detected:

Chr. 34 c.1159G>A / p.(E387K) (Missense)

Severity:

Severe. This disease has a high impact on affected animals, either with severe clinical signs causing significant suffering, or carrying a rapidly fatal course.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the LAMP3 gene will reliably determine if a dog is a genetic carrier of Fatal Neonatal Interstitial Lung Disease.

Research Citation(s):

https://pubmed.ncbi.nlm.nih.gov/32150563/

Associated Breed(s):

Airedale Terrier, Mixed Breed,

##parent-placeholder-19bd1503d9bad449304cc6b4e977b74bac6cc771##