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Eh Locus (Sable, Cocker Spaniel Type)

$50

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Test Overview:

The genetic locus EH plays a pivotal role in determining the unique sable coat coloration seen in American and English Cocker Spaniels. Dogs that carry this allele display a notable reduction in the expression of eumelanin pigment, leading to a lighter coat. This results in a distinct color gradient that transitions from golden hues to richer browns, typically concentrated on the dog’s head and back. Genetic studies have identified a specific mutation, c.250G>A, within the transmembrane domain of the MC1R gene, consistently present in dogs exhibiting the sable color phenotype.

Category:

Trait (Associated with Phenotype)

Gene:

MR1

Variant Detected:

c.250G>A

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Dominant with Variable Expressivity

Associated Breed(s):

American Cocker Spaniel, Cockapoo, Cocker Spaniel,
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