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Chondrodysplasia ITGA10 (Elkhound Type)

Chondrodysplasia ITGA10 (Elkhound Type)

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Test Overview:

Do not breed two carriers (C/T x C/T)—as this carries a 25% risk of affected puppies (T/T), 50% carriers, and 25% clear. Ideal: Breed clear dogs (C/C) to clears or carriers (C/T)—no affected offspring, but carriers may persist. Do not breed affected dogs (T/T). Long-term strategy: Gradually reduce carrier frequency while retaining genetic diversity.

Category:

Musculoskeletal - Associated with muscles, bones and associated structures

Gene:

Integrin subunit alpha 10 (ITGA10) on Chromosome 17

Variant Detected:

chr17:58703935 (canFam3): C>T

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Bingel SA, Sande RD. Chondrodysplasia in the Norwegian elkhound. Am J Pathol. 1982 May;107(2):219-29. [PubMed: 7081383] Donner J, Kaukonen M, Anderson H, Moller Fredrik, Kyostila K, Sankari S, Hytonen M, Giger U, Lohi H. Genetic Panel Screening of Nearly 100 Mutations Reveals New Insights into the Breed Distribution of Risk Variants for Canine Hereditary Disorders. PLoS One. 2016 Aug 15;11(8):e0161005. doi: 10.1371/journal.pone.0161005. [PubMed: 27525650] Kyostila K, Lappalainen AK, Lohi H. Canine chondrodysplasia caused by a truncating mutation in collagen-binding integrin alpha subunit 10. PLoS One. 2013 Sep 25;8(9):e75621. doi:10.1371/journal.pone.0075621. eCollection 2013. [PubMed: 24086591]

Associated Breed(s):

Mixed Breed, Norwegian Elkhound,

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