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Bilateral Deafness MYO7A Gene (Dobermann Type)

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Test Overview:

Do not breed affected dogs homozygous for the MYO7A mutation to prevent affected litters. Avoid carrier × carrier matings which have a 25% chance per litter of producing affected puppies. Breed carriers only to genetically clear (non-carrier) dogs to reduce risk. Routine genetic screening of breeding stock is highly recommended to limit this inherited disorder.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

MYO7A

Variant Detected:

c.3719G>A

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive with Incomplete Penetrance

Research Citation(s):

Guevar J, Olby NJ, Meurs KM, Yost O, Friedenberg SG. Deafness and vestibular dysfunction in a Doberman Pinscher puppy associated with a mutation in the PTPRQ gene. J Vet Intern Med. 2018;32:665–669. https://doi. Org/10.1111/jvim.15060 [PubMed: 29460419] Webb AA, Ruhe AL, Neff MW. A missense mutation in MYO7A is associated with bilateral deafness and vestibular dysfunction in the Doberman pinscher breed. Can J Vet Res. 2019 Apr;83(2):142-148. [PubMed: 31097876]

Associated Breed(s):

Dobermann, Mixed Breed,

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