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Amelogenesis Imperfecta (Italian Greyhound Type)

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Test Overview:

Amelogenesis Imperfecta Italian Greyhound type is a congenital teeth disorder also known as enamel hypoplasia in Italian Greyhounds.Amelogenesis Imperfecta in Italian Greyhound is affecting deciduous and permanent teeth and is manifested by enamel thinning and roughening or brownish mottling in areas of enamel thinning. It starts to develop in early adulthood of the dog. Teeth that are affected appear to be small and pointed with increased gaps. While amelogenesis imperfecta causes cavity in humans, this condition does not occur in dogs, due to maintained basic tooth structure throughout life.

Category:

Dental - Associated with the teeth and associated structures

Gene:

Enamelin (ENAM) on chromosome 13

Variant Detected:

chr13:59946494-59946498 (canFam3): 5 bp deletion (del TTTCC)

Severity:

Low. This disease generally causes mild signs of disease, or can be quite easily treated/managed.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Gandolfi B, Liu H, Griffioen L, Pedersen NC. Simple recessive mutation in ENAM is associated with amelogenesis imperfecta in Italian greyhounds. Anim Genet. 2013 Aug;44(5):569-78. [PubMed: 23638899]

Associated Breed(s):

Italian Greyhound, Mixed Breed,

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