/ 0

Store

Acute Respiratory Distress Syndrome (Dalmatian Type)

$50

(ONLINE PRICE)

ADD TO CART

Test Overview:

Do not breed affected dogs (homozygous mutants) as the disease is fatal. Avoid carrier x carrier matings, which have a 25% chance of producing affected puppies. Breed carriers only to genetically clear (non-carrier) dogs to prevent affected offspring; note that some puppies will be carriers. Routine genetic testing for ANLN mutations in breeding Dalmatians is strongly recommended to reduce the incidence of the disease. Breed clubs and genetic counseling services can provide guidelines to help reduce or eliminate this mutation from the population while maintaining genetic diversity.

Category:

Respiratory - Associated with the lungs and respiratory system

Gene:

Anillin actin binding protein (ANLN) on chromosome 14

Variant Detected:

chr14:47912313 (canFam3): C/T

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Holopainen S, Hytonen MK, Syrja P, Arumilli M, Jarvinen AK, Rajamaki M, Lohi H. ANLN truncation causes a familial fatal acute respiratory distress syndrome in Dalmatian dogs. PLoS Genet. 2017 Feb 21;13(2):e1006625. doi: 10.1371/journal.pgen.1006625. [PubMed: 28222102] Jarvinen A, Saario E, Andresen E, Happonen I, Saari S, Rajamaki M. Lung Injury Leading to Respiratory Distress Syndrome in Young Dalmatian Dogs. J Vet Intern Med. 1995 May-Jun;9(3):162-8. [PubMed: 7674217]

Associated Breed(s):

Dalmatian, Mixed Breed,

##parent-placeholder-19bd1503d9bad449304cc6b4e977b74bac6cc771##