Mucopolysaccharidosis VI (Great Dane Type)

Category:

Metabolic - Associated with the enzymes and metabolic processes of cells

Gene:

ARSB

Variant Detected:

c.295C>T

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the ARSB gene will reliably determine if a dog is a genetic carrier of Mucopolysaccharidosis VI (Great Dane Type).

Research Citation(s):

Vet Pathol. 2018 Mar;55(2):286-293

Associated Breed(s):

Great Dane, Mixed Breed,