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Congenital Hypothyroidism with Goiter (Toy Fox Terrier Type)

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Test Overview:

Test all breeding dogs for the TPO gene mutation. Avoid mating two carriers to prevent producing affected puppies. Breed carriers only to clear dogs. Do not breed affected dogs. Gradually reduce mutation prevalence via genetic testing and selective breeding while maintaining genetic diversity.

Category:

Endocrine - Associated with hormone-producing organs

Gene:

Thyroid peroxidase (TPO) on chromosome 17

Variant Detected:

c.331C>T transition

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Fyfe JC, et al. Congenital Hypothyroidism with Goiter in Toy Fox Terrier. (2003) J Vet Intern Med,17;50–57.

Associated Breed(s):

Mixed Breed, Rat Terrier, Toy Fox Terrier,

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