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Cardiomyopathy and Juvenile Mortality (Belgian Shepherd)

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Test Overview:

Do not breed affected dogs (homozygous for the YARS2 mutation) as all offspring would inherit the mutation. Avoid carrier × carrier matings, which have a 25% risk of producing affected puppies. Breed carriers only to genetically clear (non-carrier) dogs, which results in no affected puppies but some carriers, aiding genetic diversity. Routine genetic screening is strongly recommended in Belgian Shepherd breeding programs to reduce disease incidence.

Category:

Cardiorespiratory (Associated with Heart and Lungs)

Gene:

YARS2, chr13

Variant Detected:

c.1054G>A

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the YARS2 gene in dogs will reliably determine if it is a genetic carrier of Cardiomyopathy and Juvenile Mortality.

Research Citation(s):

Gurtner C, Hug P, Kleiter M, Köhler K, Dietschi E, Jagannathan V, Leeb T. YARS2 Missense Variant in Belgian Shepherd Dogs with Cardiomyopathy and Juvenile Mortality. Genes (Basel). 2020 Mar 14;11(3):313. [PubMed: 32183361]

Associated Breed(s):

Belgian Groenendael Shepherd, Belgian Lakenois Shepherd, Belgian Malinois Shepherd, Belgian Tervueren Shepherd , Mixed Breed,

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