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Canine Multiple System Degeneration (Kerry Blue Terrier Type)

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Test Overview:

Canine multiple system degeneration (Kerry blue terrier type) is a progressive inherited neurological disease affecting Kerry blue terriers. Affected dogs present at 3 to 6 months of age with tremors, abnormal gait and poor balance. Dogs gradually progress to severe gait abnormalities and balance issues, frequent falling, abnormal body posture, abnormal eye movement and eventually, are unable to move. Dogs continue to show normal mental awareness and social behavior despite movement disturbances. Most dogs die due to disease complications or are humanely euthanized by 2 years of age.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

Serine active site containing 1 (SERAC1) on chromosome 1

Variant Detected:

chr1:47605147 (canFam3): C>T

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Johnson GS, Mhlanga-Mutangadura T, Morava E, Kozicz T, Taylor JF, O’Brien DP, Schnabel RD. Canine Multiple System Degeneration is Associated with Distinct SERAC1 Mutations in Two Different Dog Breeds [abstract]. Presented at the 63rd Annual Meeting of the American Society of Human Genetics in Boston, Massachusetts; 2013 Oct 22-26.

Associated Breed(s):

Kerry Blue Terrier, Mixed Breed,

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