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Canine Multiple System Degeneration (Kerry Blue Terrier Type)

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Test Overview:

Do not breed affected dogs homozygous for the SERAC1 mutation to prevent producing affected litters. Avoid carrier × carrier matings, as there is a 25% chance per litter of producing affected puppies. Breed carriers only to genetically clear (non-carrier) dogs; this produces no affected puppies but some carriers. Routine genetic testing of breeding stock in Kerry Blue Terriers is strongly recommended. Responsible breeding balances disease reduction with maintenance of genetic diversity.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

Serine active site containing 1 (SERAC1) on chromosome 1

Variant Detected:

chr1:47605147 (canFam3): C>T

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the SERAC1 gene in Kerry blue terriers will reliably determine if a dog is a genetic carrier of canine multiple system degeneration (Kerry blue terrier type).

Research Citation(s):

Johnson GS, Mhlanga-Mutangadura T, Morava E, Kozicz T, Taylor JF, O’Brien DP, Schnabel RD. Canine Multiple System Degeneration is Associated with Distinct SERAC1 Mutations in Two Different Dog Breeds [abstract]. Presented at the 63rd Annual Meeting of the American Society of Human Genetics in Boston, Massachusetts; 2013 Oct 22-26.

Associated Breed(s):

Kerry Blue Terrier, Mixed Breed,

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