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Primary Open Angle Glaucoma and Primary Lens Luxation (Shar Pei Type)

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Test Overview:

Primary Open Angle Glaucoma and Primary Lens Luxation (Shar Pei Type) affects dogs and is an inherited eye disease. Dogs affected with this disorder present with excessive eye pressure before 6 years of age, resulting in enlargement of the eye and pain that is poorly responsive to treatment. Signs of pain in the eye can include excessive blinking, tearing and redness. If this is left untreated, the increased pressure leads to bulging eyes, optic nerve damage and the gradual loss of vision. Additionally, affected dogs may also be predisposed to dislocation (luxation) of the lens in the eye which may exacerbate glaucoma.

Category:

Ophthalmologic - Associated with the eyes and associated structures

Gene:

ADAMTS17

Variant Detected:

chr3:40935387-40935393: 6 bp deletion (del CGTGGT)

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Eye examination Genetic testing of the ADAMTS17 gene will reliably determine if a dog is a genetic carrier of primary open angle Glaucoma and primary lens luxation (shar-pei type).

Research Citation(s):

https://pubmed.ncbi.nlm.nih.gov/29287154/ Oliver JAC, Rustidge S, Pettitt L, Jenkins CA, Farias FGH, Giuliano EA, Mellersh CS. Evaluation of ADAMTS17 in Chinese Shar-Pei with primary open-angle glaucoma, primary lens luxation, or both. Am J Vet Res. 2018 Jan;79(1):98-106. doi: 10.2460/ajvr.79.1.98. [PubMed: 29287154]

Associated Breed(s):

Shar Pei,

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