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Neuroaxonal Dystrophy (Spanish Water Dog Type)

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Test Overview:

Neuroaxonal Dystrophy (Spanish water dog type) affects dogs and is an inherited progressive neurological disorder. Affected dogs will generally present with an abnormal gait, nervousness, incontinence, and behaviour changes including dullness, and vocalisation between 6 months to 1 year of age. Some dogs may also display vision loss and decreased muscle tone. Dogs are typically euthanised within a year of diagnosis as a result of disease progression.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

TECPR2

Variant Detected:

-

Severity:

Severe. This disease has a high impact on affected animals, either with severe clinical signs causing significant suffering, or carrying a rapidly fatal course.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the TECPR2 gene will reliably determine if a dog is a genetic carrier of neuroaxonal dystrophy (Spanish water dog type).

Research Citation(s):

Hahn K, Rohdin C, Jagannathan V, Wohlsein P, Baumgartner W, Seehusen F, Spitzbarth I, Grandon R, Drogemüller C, Jaderlund KH. TECPR2 Associated Neuroaxonal Dystrophy in Spanish Water Dogs. PLoS One. 2015 Nov 10;10(11). [PubMed: 26555167]

Associated Breed(s):

Spanish Water Dog,

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