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Episodic Falling Syndrome (Cavalier Type)

Episodic Falling Syndrome (Cavalier Type)

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Test Overview:

Test breeding stock for the BCAN mutation to identify carriers and affected dogs. Avoid breeding two carriers to prevent affected puppies. Breed carriers only to clear dogs with offspring tested before breeding. Maintain genetic diversity while reducing the frequency of EFS.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

Brevican (BCAN) Chromosome 7

Variant Detected:

Nucleotide Deletion and Nucleotide Insertion 15.7 kb deletion ins(GGCCTT)

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the BCAN gene will reliably determine if a dog is a genetic carrier of episodic falling syndrome.

Research Citation(s):

Gill JL, et al. A canine BCAN microdeletion associated with episodic falling syndrome. (2012) Neurobiol Dis 45;130-136.

Associated Breed(s):

Bernardoodle, Cavador, Cavalier King Charles Spaniel, Cavoodle, King Charles Spaniel, Mixed Breed,

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