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Curly Coat Dry Eye Syndrome (Cavalier Type)

Curly Coat Dry Eye Syndrome (Cavalier Type)

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Test Overview:

Test all breeding Cavaliers for the FAM83H mutation. Avoid breeding two carriers to prevent producing affected puppies. Breed carriers only to genetically clear dogs. Do not breed affected dogs. Maintain genetic diversity by using genetic testing alongside pedigree information. Educate breeders on the importance of testing to reduce disease incidence responsibly.

Category:

Ophthalmologic - Associated with the eyes and associated structures

Gene:

FAM83H

Variant Detected:

chr13:37328055 (canFam3): 1 bp deletion (del C)

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the FAM83H gene will reliably determine if a dog is a genetic carrier of dry eye curly coat syndrome.

Research Citation(s):

Barnett KC. Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis in the cavalier King Charles spaniel. J Small Anim Pract. 2006 Sep;47(9):524-8. [PubMed: 16961470] Hartley C, Donaldson D, Smith KC, Henley W, Lewis TW, Blott S, Mellersh C, Barnett KC. Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis in 25 Cavalier King Charles spaniel dogs - Part I: clinical signs, histopathology, and inheritance. Vet Ophthalmol. 2012 Sep;15(5):315-26. [PubMed: 22212237]

Associated Breed(s):

Bernardoodle, Cavador, Cavalier King Charles Spaniel, Cavoodle, Unknown,

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